For a group of 1940s big band musicians with dreams of fame and fortune, the music, the women, the dreams lost... are all just Blues in the Night. Virtuoso blues pianist Jigger Pine (Richard Whorf) forms a band and hits the road, always low on cash and looking for one big break. But when Jigger meets Kay Grant (Betty Field) in a dive bar, he leaves the band and follows her to New York, where he discovers that she doesn't love him... and that he loves alcohol. Jigger eventually returns to his band, but Kay follows and threatens to once again destroy Jigger. Now, will one of the musicians do what needs to be done to save both Jigger and the band?