William Lee (Daniel Craig), a solitary American expat in Mexico City in 1950, spends his days drinking, writing, and searching for something. He discovers it in the young former soldier Eugene Allerton (Drew Starkey), an elusive Oklahoman who finds himself the object of the older man’s affections. Journeying together into the Ecuadorian jungle in search of the mythical, psychedelic yagé, Lee sees, for the first time, the possibility of an intimate and infinite love. From acclaimed filmmaker Luca Guadagnino comes a new romance, and an adventure to the ends of the earth and the limits of perception, based on the novel by counterculture icon William S. Burroughs.