Dr. Oliver Wolf is an eccentric but incredibly gifted neurologist who suffers from a rare condition that gives him a unique perspective on care, fueling his mission to change the way the world sees his patients. After his unusual methods result in his dismissal, he takes his unconventional approach to a new hospital: Bronx General, where he leads a team of bright young interns in tackling some of the world's most puzzling psychological cases. With their help, he must also challenge his own personal and social limitations by navigating all the expectations, politics and complicated relationships that come with the job.